Omega-3 fatty acid supplementation changes intracellular phospholipase A activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis

S Smesny; B Milleit; M Otto; I Nenadic; H Sauer; U-C Hipler; C Milleit; MR Schäfer; GP Amminger; PD McGorry; CM Klier; M Holub; I Holzer; GE Berger; M Berk

Journal article

Omega-3 fatty acid supplementation changes intracellular phospholipase A activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis

S Smesny, B Milleit, M Otto, I Nenadic, H Sauer, U-C Hipler, C Milleit, MR Schäfer, GP Amminger, PD McGorry, CM Klier, M Holub, I Holzer, GE Berger, M Berk

Molecular Psychiatry | Published : 2013

DOI: 10.1038/mp.2013.7

Abstract

The identification of an ultra-high risk (UHR) profile for psychosis and a greater understanding of its prodrome have led to increasing interest in early intervention to delay or prevent the onset of psychotic illness. In a randomized placebo-controlled trial, we have identified long-chain ω-3 (ω-3) polyunsaturated fatty acid (PUFA) supplementation as potentially useful, as it reduced the rate of transition to psychosis by 22.6% 1 year after baseline in a cohort of 81 young people at UHR of transition to psychosis. However, the mechanisms whereby the ω-3 PUFAs might be neuroprotective are incompletely understood. Here, we report on the effects of ω-3 PUFA supplementation on intracellular pho..

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University of Melbourne Researchers

Paul Amminger Author

Patrick McGorry Author

Michael Berk Author

Related Projects (2)

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EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

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Grants

Awarded by Stanley Medical Research Institute

Awarded by German Research Foundation (DFG)

Awarded by National Health and Medical Research Council, Australia

Funding Acknowledgements

The study was supported by Stanley Medical Research Institute, Grant 03T-315. In performing inPLA<INF>2</INF> analysis, Dr Stefan Smesny was supported by German Research Foundation (DFG), Grant Sm 68/3-1. Dr G Paul Amminger was supported by Grant 566529 from the National Health and Medical Research Council, Australia. Dr Sherilyn Goldstone edited the final manuscript; Margit Kornsteiner and Jessica Slavik assisted with the erythrocyte FA analysis; Kostas Papageorgiou assisted with psychiatric research assessments. We thank all of the participants and their families.